Joeanna Sayler was born in Princeton, New Jersey. At the age of sixteen she moved to New York City where she began to work as a model. After finding success in New York she moved to Milan and Hamburg where she lived and worked.

Joeanna caught the acting bug when she was featured in two Woody Allen movies, Deconstructing Harry and Celebrity. She moved to Los Angeles at the age of nineteen to pursue acting.

Soon after moving to Los Angeles, she landed roles on the tv shows Friends and Bram and Alice. In 2004 Joeanna was cast in the ABC pilot Naked Hotel in which she starred opposite John Corbett. She was last seen in the feature film A Lot Like Love opposite Ashton Kutcher.

Joeanna has recently completed shooting the independent feature Trust Me.